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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12462 | PI3Kδ-IN-1 | PI3K | |
PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM). | |||
T63497 | PI3Kδ/γ-IN-1 | ||
PI3Kδ/γ-IN-1 is a selective and effective inhibitor of PI3Kδ/γ that can be used in the treatment of hematologic malignancies. | |||
T36083 | DS-7423 | PI3K , mTOR | |
DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2]. DS-7423 increases TP53 expression, the level of p-TP53 on Ser... | |||
T63078 | PI3Kδ/γ-IN-3 | ||
PI3Kδ/γ-IN-3 (Compound 58) is an orally active dual inhibitor of PI3Kδ (IC50: 1 nM) and PI3Kγ (IC50: 16 nM). PI3Kδ/γ-IN-3 can induce apoptosis of tumor cells, which can be used in the study of B-cell malignant tumors. | |||
T78568 | PI3Kδ-IN-15 | PI3K | |
PI3Kδ-IN-15 (compound 6b) is a potent and selective inhibitor of PI3Kδ, exhibiting an IC50 of 0.5 nM for p110δ and demonstrating over 30-fold selectivity compared to PI3K isoforms γ, β, and α [1]. | |||
T63221 | PI3Kδ/γ-IN-2 | ||
PI3Kδ/γ-IN-2 is a potent, orally bioavailable dual inhibitor of PI3Kδ (IC50: 1 nM) and PI3Kγ (IC50: 4.3 nM) with potential for use in anti-B-cell malignancy studies. | |||
T79627 | PI3Kδ-IN-13 | PI3K | |
PI3Kδ-IN-13 (compound 89), with an IC50 value of 2.6 nM, is an inhibitor of PI3Kδ, applicable for researching diseases involving cell proliferation, including cancer, infection, inflammation, and autoimmune disorders [1]... | |||
T78691 | PI3Kδ-IN-12 | PI3K | |
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4 for PI3Kβ, and 6.7 for PI3Kα. This compound is utilized in r... | |||
T79658 | PI3Kδ-IN-14 | PI3K | |
PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain of PI3Kδ. This compound exhibits anti-inflammatory properties b... | |||
T81468 | PI3Kδ-IN-17 | PI3K | |
PI3Kδ-IN-17 (Compound S5) is a potent PI3K δ inhibitor, exhibiting an IC50 value of 2.82 nM and demonstrates significant efficacy in suppressing the proliferation of SU-DHL-6 cells with an IC50 of 0.035 μM [1]. | |||
T81467 | PI3Kδ-IN-18 | PI3K | |
Se15, a selective PI3Kδ inhibitor, exhibits potency with an IC50 value of less than 0.1nM and is utilized in autoimmune research [1]. | |||
T62997 | PI3K/AKT-IN-1 | ||
PI3K/AKT-IN-1 is a potent, dual PI3K/AKT inhibitor that acts on PI3Kγ (IC50: 6.99 μM), PI3Kδ (IC50: 4.01 μM) and AKT (IC50: 3.36 μM). PI3K/AKT-IN-1 induces caspase 3-dependent apoptosis by inhibiting the PI3K/AKT pathway... | |||
T72465 | Umbralisib tosylate | RP5264 tosylate,TGR-1202 tosylate ; RP5264 tosylate,TGR-1202 tosylate | |
Umbralisib Tosylate (TGR-1202) is a potent, selectively dual inhibitor targeting PI3Kδ and casein kinase-1-ε (CK1ε), demonstrating oral activity. With EC50 values of 22.2 nM and 6.0 μM for PI3Kδ and CK1ε respectively, it... | |||
T74360 | MEK/PI3K-IN-1 | ||
MEK/PI3K-IN-1 (compound 6r) is a potent inhibitor targeting both MEK and PI3K, exhibiting IC50 values of 124 nM for MEK1, 130 nM for PI3Kα, and 236 nM for PI3Kδ. It effectively reduces levels of pAKT and pERK1/2, demonst... | |||
T74361 | MEK/PI3K-IN-2 | ||
MEK/PI3K-IN-2 (compound 6s), a potent inhibitor of both MEK and PI3K, demonstrates IC50 values of 352 nM (MEK1), 107 nM (PI3Kα), and 137 nM (PI3Kδ). This compound effectively reduces pAKT and pERK1/2 levels, exhibiting a... | |||
T61654 | PI3Kα-IN-9 | ||
PI3Kα-IN-9 (compound 27) is a highly specific, orally active, and long-lasting inhibitor of PI3Kα, demonstrating potent inhibitory effects with IC50 values of 4.4, 128, 146, and 153 nM against PI3Kα, PI3Kγ, PI3Kδ, and PI... | |||
T72527 | Umbralisib sulfate | TGR-1202 sulfate ; RP-5264 sulfate,TGR-1202 sulfate,RP-5264 sulfate | |
Umbralisib (TGR-1202) sulfate, an orally active compound, serves as a potent, selective inhibitor targeting both PI3Kδ and casein kinase-1-ε (CK1ε), with EC50 values of 22.2 nM and 6.0 μM, respectively. It demonstrates u... | |||
T35531 | FD223 | ||
FD223 is a potent, selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor with a marked affinity (IC50=1 nM), demonstrating notable selectivity against other isoforms (IC50s: α=51 nM, β=29 nM, γ=37 nM). This compoun... | |||
T36308 | PF-06843195 | ||
PF-06843195 is a selective PI3Kα inhibitor, demonstrating potent activity with an IC50 of 18 nM in Rat1 fibroblasts and Kis for PI3Kα and PI3Kδ less than 0.018 nM and 0.28 nM, respectively, in biochemical kinase assays. ... | |||
T35488 | (S)-PI3Kα-IN-4 | (S)-PI3Kα-IN-4 | |
(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the... |